This was a summary paper written for presentation as part of my undergraduate research endeavours. https://www.scribd.com/document/414739616/The-Old-Grey-Mare-America-s-Old-Brown-Dog-Misogyny-and-Medicine-Anti-Vivisectionist-Women
This document is a set of the annotations I prepared for Mrs. Frisby and the Rats of NIMH. Due to the obvious copyright restrictions, I cannot post the text of the book with the annotations. For now, I have organized by chapter and will shortly update this document to include the words/phrase to which the annotation refers and the page number in a first printing of the hardcover copy of book from Atheneum 1978. https://www.scribd.com/document/414739252/Personal-Annotations-for-Mrs-Frisby-and-the-Rats-of-NIMH-NO-BOOK-TEXT-Arahshiel-Rose-Silver
NOTE: This information is provided for educational purposes ONLY. It is NOT in any way intended for any for-profit purposes. All measures have been taken to avoid any copyright infringement. The current owner of copyright is Simon & Schuster and you can purchase a copy of the book from Amazon here: https://www.amazon.com/Mrs-Frisby-Rats-Robert-OBrien/dp/0689710682/ref=sr_1_1?crid=2Z81ZCBZCAT94&keywords=mrs+frisby+and+the+rats+of+nimh+book&qid=1561646947&s=gateway&sprefix=mrs+fr%2Caps%2C136&sr=8-1
“This demonstration may surely be classed, partially at least, as the good resulting from intended evil. The dreadful experiment of Professor Watson, which bids fair to make Chicago’s “tortured rat” as well-known as was “the brown dog” of transatlantic fame, aroused thousands to the possibilities of vivisection mania. In an editorial, as clever as it was caustic, a journal of our own city, never committed to the specific support of Anti-vivisection, said in a recent issue: “The Chicago professor may have demonstrated to his own satisfaction that rats possess the sixth sense of direction; he certainly demonstrated to the world at large another medical fact, namely, that scientists can live without hearts” – which was probably more than Professor Watson set out to prove!”
Rats and mice may be considered ‘animals’ in phylogenetic trees, in zoology and in the public mind, however, when it comes to legal protections as awarded in the Animal Welfare Act of 1970, they are not considered animals at all. Even today, people are often surprised at the efforts of humane societies and other groups who work to rescue and adopt out rats; the idea of a ‘humane society’ typically causes most people to think solely of cats and dogs, or, occasionally rabbits or guinea pigs. Caroline Earle White and other activists, however, were outraged at cruelty to every animal, and, in the case of Dr. Watson, that fury made national news.
“An experiment upon a rat having been performed by Professor Watson of Chicago which on account of its cruelty aroused the indignation of the whole country, judging from the articles in the newspapers, your Corresponding Secretary wrote to a prominent anti-vivisectionist of Chicago, Mr. Sydney R. Taber, asking him to use his influence in the Humane Society of Illinois to induce the President to institute a prosecution of Dr. Watson. Mr. Taber in his reply said that the Illinois Society had been investigating the subject but had not succeeded in obtaining the evidence to prove that the barbarous experiment had been performed by Professor Watson.” The Philadelphia Record
It was Professor Watson of the Chicago University who drew national attention to the kinds of experiments that could be done on animals, and, in this case, “which on account of its cruelty aroused the indignation of the whole country, judging from the articles in the newspapers, (1907)” The experiment involved the gradual removal of all five sense from rats in order to determine whether or not they had a sixth sense. The progression was as follows: first, the eyes were removed and their feet were frozen. After this, they were, according to Watson’s own words, “[turned] them loose, to observed if they possessed any instinct of the direction they ought to take.” According to the accounts, such experiments proved to Watson that “that the inferior animals do possess one sense more than others – the sense of direction.” The article that detailed the above description closed with the following sentence which clearly shows that such experimentation was not felt necessary: “Rats and mice, it would seem, can manage to get along somehow without the aid of eyes and tails, and so can scientists without hearts.” – Philadelphia Standard and Times.
The issue of cattle transportation, although not usually immediately associated with the popular perception of ‘humane societies,’ was always high on Caroline Earle White’s list of concerns. In 1876, seven years before the founding of the AAVS, she went as far as to say that “[n]ext to cattle transportation, the evil which we have felt has most demanded our attention is Vivisection.” Her watering fountains, distributed throughout Philadelphia, supported not only horses and dogs, but also served to quench the thirst of cattle, with the WSPCA citing at least once incident of a near-stampede of cattle to one of the fountains in 1890. Some of these fountains remain standing today after many years of service. Pictured below is the one founded with a bequest from long-time WSPCA member, Annie L. Lowry. (On the right, see Caroline Earle White in black, and, to the left, a photo of the author in December 2014.)
For example, In 1910 they boasted that their twenty-six fountains had watered 300,711 horses, 25,499 smaller animals and 170,652 had a drink. 
1. Women’s Branch of the Pennsylvania Society for the Prevention of Cruelty to Animals. Seventh Annual Report of the Women’s Branch of the Pennsylvania Society for the Prevention of Cruelty to Animals. Philadelphia, 1876, page 4.
2. Women’s Branch of the Pennsylvania Society for the Prevention of Cruelty to Animals. Forty First Annual Report of the Women’s Branch of the Pennsylvania Society for the Prevention of Cruelty to Animals, 1910, page 7.